Two types of granules were observed in the neutrophils of red seabream Pagrus major infected with body surface cloudiness (BSC). Both granule types had similar morphologies but different cytochemical characteristics to those of ordinary chromophobic granules (oβG-1, oβG-2) from non-infected fish. In this paper, we called the two granule-types from the fish infected with BSC to extraordinary chromophobic granules (type 1, eoβG-1^{BSC}； type 2, eoβG-2^{BSC}). The eoβG-1^{BSC} showed chromophobic, simple morphology (without stratified structure), peroxidase positive, SBB negative and lack of lysozomal enzymes. The eoβG-2^{BSC} was stratified granule with two-layer structure (inner eosinophilic layer (L0) and outer chromophobic layer (L1)). Lysozomal enzymes (acid phosphatase, β-glucuronidase (β-Glu) and esterases) and peroxidase (PO) were localized in L0 and L1, respectively. Both types of extraordinary granules were Sudan black B negative. Spot formation, a curious phenomenon appeared in PO- stained oβG-2 (positive L1 and negative L0), was not observed in eoβG-2^{BSC}. Almost all L0 of eoβG-2^{BSC} were β-Glu positive. Contrastively, this enzyme activity was detected in a few L0 of oβG-2.