Two types of granules observed in the neutrophils of red seabream Pagrus major infected with protozoean parasites: Amyloodinium ocellatum (Ao) and Cryptocaryon irritans (Ci). However, morphological and cytochemical characteristics of the granules were different in each parasite. The granules from the fish with parasitized Ao were classified in extraordinary chromophobic granule (eoβG-2^{Ao}) and inducible chromophobic granule (iβG^{Ao}). The former had similar morphology to that of ordinary chromophobic granule (oβG-2) from non-infected fish； eosinophilic granule core (layer around the center of granule, L0) and chromophobic surrounding area of L0 (layer around the L0, L1). However, eoβG-2^{Ao} showed lack of acid phosphatase, increase of β-glucuronidase-positive L0, non-formation of spot on peroxidase (PO) staining preparation, and positive reaction to oil red O (ORO) and Sudan III in L1. The iβG^{Ao} had two-layer structure (chromophobic L0 and L1) and the L0 was PO, Sudan black B (SBB), ORO and Sudan III positive. On the other hand, neutrophil granules from the fish with parasitized Ci were classified in type 1 and type 2 extraordinary chromophobic granule (eoβG-1^{Ci}, eoβG-2^{Ci}) with similar structure and cytochemical character to that of two types of ordinary chromophobic granule (oβG-1, oβG-2) from non-infected fish except for SBB: The eoβG-1^{Ci} and eoβG-2^{Ci} were SBB negative.