New two neutrophil types, sixth (N-6) and seventh type (N-7), were observed in the blood of Ceratothoa verrucosa (Cv)-infested (usual parasitism； N-6 and N-7 from two Cv-infested individual, N-7 from one Cv-infested individual) red seabream Pagrus major with exophthalmos. The bulging eyes contained bubbles. The N-6 and N-7 were observed in the infested fish without or with mouth insufficiency (MI； Mouth closure was incomplete), respectively； the exophthalmos occurred prior to MI (EP→MI).