Three types of granules, two extraordinary types and one inducible type, were observed in the neutrophils of red seabream Pagrus major infected with Tenacibaculum maritimum. Both extraordinary granule types (eoG1^{Tm}, eoG2^{Tm}) had similar morphologies but different cytochemical characteristics to those of ordinary granules (oG1^N, oG2^N) from non-infected fish. The eoG1^{Tm} showed chromophobic, simple morphology (without stratified structure), peroxidase positive and lack of lysozomal enzymes. The eoG2^{Tm} was stratified granule with three-layer structure [inner eosinophilic layer (L0-0), middle chromophobic layer (L0-1) and outer chromophobic layer (L1)]. Acid phosphatase, ꞵ-glucuronidase (ꞵ-Glu), α-naphtyl acetate esterase and naphthol AS-D chloroacetate esterase were detected in L0-0, but α-naphtyl butylate esterase was in L0 (L0-0 and L0-1). Peroxidase (PO) were localized in L1. Both extraordinary types were Sudan black B (SBB) negative. Spot formation, a curious phenomenon appeared in PO-stained oG2^N (positive L1 and negative L0), was not observed in eoG2^{Tm}. Inducible granule (iG^{Tm}) was consisted of two chromophobic layers (inner L0 and outer L1). The L0 of iG^{Tm} showed positive reaction to PO.