部局大学院医学系研究科(医学)
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Background and Aim: Image definition and complete small bowel examination rate are possible factors contributing to missed lesions during capsule endoscopy.This study aimed to determine the effect of coadministration of polyethylene glycol (PEG) and dai-kenchu-to (DKT) on these factors using PEG and DKT as pretreatment before capsule endoscopy. Methods: Patients who underwent capsule endoscopy at our hospital between November 2007 and August 2012 were included in the study. Patients were divided into the following three groups: those receiving no pretreatment (control, n=133), those orally administered PEG (PEG, n=20), and those orally administered PEG and DKT (15g) (PEG + DKT, n=25). Image definition and complete small bowel examination rate were examined retrospectively between the three groups. Results: Image definition in the PEG + DKT group was significantly higher than that in the control group (p<0.05), but there was no significant differences between the PEG and control groups. The complete small bowel examination rate was significantly lower in the PEG group than in the control and PEG + DKT groups (p<0.05). Conclusions: Coadministration of PEG and DKT improved image definition and prevented a reduction of the complete small bowel examination rate due to PEG in capsule endoscopy.
作成者 : Suzuki Keiko | 橋本 真一 | 白澤 友宏 | Yokota Tadayuki | Kaneyama Satoko | 柴田 大明 | Tanabe Ryo | 坂井田 功 出版者 : Yamaguchi University School of Medicine 発行日 : 2014
Pathology of the inner ear after acoustic injury
The bulletin of the Yamaguchi Medical School 61 巻 1-2 号
作成者 : Kanagawa Eiju | 菅原 一真 | 廣瀬 敬信 | 御厨 剛史 | 下郡 博明 | 山下 裕司 出版者 : Yamaguchi University School of Medicine 発行日 : 2014
作成者 : 竹本 圭宏 | 榎 忠彦 | 田中 裕也 | 原田 栄二郎 | 濱野 公一 出版者 : Yamaguchi University School of Medicine 発行日 : 2013
作成者 : Tamon Hiroki | Mahbub MH | Harada Noriaki 出版者 : Yamaguchi University School of Medicine 発行日 : 2013
作成者 : Akashi Shintaro | Miura Toshiro | Shibuya Masaki | Fukagawa Yasuhiro | Oda Takamasa | 中村 武史 | Ikeda Yasuhiro | Matsuzaki Masunori | 矢野 雅文 出版者 : Yamaguchi University School of Medicine 発行日 : 2013
作成者 : Fukagawa Yasuhiro | Miura Toshiro | Shibuya Masaki | Akashi Shintaro | Oda Takamasa | 中村 武史 | Matsuzaki Masunori | 矢野 雅文 出版者 : Yamaguchi University School of Medicine 発行日 : 2013
作成者 : 中野 旬之 | 真野 隆充 | 三島 克章 | 岸 正海 | 堀永 大樹 | Miyawaki Yuichiro | 森 悦秀 | 上山 吉哉 出版者 : Yamaguchi University School of Medicine 発行日 : 2012
作成者 : 山城 安啓 | 服部 幸夫 | 新田 孟徳 | Adhiyanto Chris | Matar Maryam M. | Ferania Mella | 高木 文也 出版者 : Yamaguchi University School of Medicine 発行日 : 2012
Melatonin protects oocyte from reactive oxygen species
The bulletin of the Yamaguchi Medical School 59 巻 3-4 号
作成者 : 田村 博史 | 高崎 彰久 | 竹谷 俊明 | 田邊 学 | 木塚 文恵 | 李 理華 | 田村 功 | 前川 亮 | 浅田 裕美 | 山縣 芳明 | 杉野 法広 出版者 : Yamaguchi University School of Medicine 発行日 : 2012
作成者 : 藤田 基 | 前川 剛志 | 戸谷 昌樹 | 鶴田 良介 出版者 : Yamaguchi University School of Medicine 発行日 : 2012
Catecholaminergic polymorphic ventricular tachycardia (CPVT) is an inherited disease characterized by stress- or exercise- induced ventricular tachycardia, frequently leading to sudden cardiac death. A considerable body of evidence accumulated over recent years suggests that mutation-linked cardiac ryanodine receptor (RyR2) defects cause Ca^2+ leak from sarcoplasmic reticulum, which triggers delayed afterdepolarization and leads to CPVT. However, the underlying mechanism, by which a single mutation in such a large molecule causes drastic effects on the channel function, remains elusive. Here we report that introduction of a human CPVT mutation S2246L into the mouse RyR2 induces aberrant activation of channel gating by forming abnormally tight domain-domain interaction between the S2246L mutable domain and the K201-binding domain. This produces more global conformational change in the RyR2: namely, an aberrant domain unzipping between the N-terminal (a.a. 1–600) domain and the central (a.a. 2000–2500) domain owing to the allosteric conformational coupling mechanism. Pharmacological correction of the defective inter-domain interactions can stop the aberrant Ca^2+ release and lethal arrhythmia. These results provide a new pathogenic mechanism of CPVT and a novel therapeutic strategy against CPVT
作成者 : 末冨 建 | 矢野 雅文 | 松﨑 益徳 出版者 : Yamaguchi University School of Medicine 発行日 : 2012
Neuromuscular responses to acute whole body vibration in healthy young men
The bulletin of the Yamaguchi Medical School 59 巻 1-2 号
作成者 : 廣滋 恵一 | 原田 規章 | Mahbub MH 出版者 : Yamaguchi University School of Medicine 発行日 : 2012
The immune-mediated pathogenesis and treatment of aplastic anemia
The bulletin of the Yamaguchi Medical School 59 巻 1-2 号
作成者 : 篠原 健次 出版者 : Yamaguchi University School of Medicine 発行日 : 2012
作成者 : 谷田 憲俊 出版者 : Yamaguchi University School of Medicine 発行日 : 2012
作成者 : 根本 圭 | 武藤 正彦 出版者 : Yamaguchi University School of Medicine 発行日 : 2011
作成者 : 豊田 英樹 | 下郡 博明 | 菅原 一真 | 山下 裕司 出版者 : Yamaguchi University School of Medicine 発行日 : 2011
作成者 : 田中 増郎 | 林 俊輔 | 富士岡 隆 | 戸部 郁代 | 中村 彰治 出版者 : Yamaguchi University School of Medicine 発行日 : 2011
作成者 : 内海 仁志 | 矢野 雅文 | 松﨑 益徳 出版者 : Yamaguchi University School of Medicine 発行日 : 2011
作成者 : 石川 浩三 出版者 : Yamaguchi University School of Medicine 発行日 : 2010
Arteriosclerosis and vascular endothelial function in chronic liver disease
The bulletin of the Yamaguchi Medical School 57 巻 3-4 号
作成者 : 末永 弘美 | 坂井田 功 | Korenaga Keiko | 岡本 健志 | 瀬川 誠 | 内田 耕一 | 日野田 裕治 出版者 : Yamaguchi University School of Medicine 発行日 : 2010
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