Background: Less aggressive rectal neuroendocrine tumors (NETs) are mainly located in the submucosal layer. We analyze our clinical experience of endoscopic submucosal dissection (ESD) for rectal NETs. Methods: We experienced 27 consecutive rectal neuroendocrine neoplasms (NENs). In these cases, we retrospectively analyzed our selections and the therapeutic results of endoscopic mucosal resection (EMR) and ESD. Results: We initially used EMR for rectal NETs. However, there was one case of local recurrence with adjacent lymph-node metastasis. This was initially treated by EMR at another hospital 12 years earlier. We changed the resection modality from EMR to ESD, which has been useful for en bloc resection. Thereafter, we performed ESD for 16 cases. En bloc resection was performed in 15 cases. The vertical margin was positive in one case but there was no local residue. In one ESD case, detailed examination of the ESD en bloc specimen clarified lymphovascular invasion and was useful for the decision of additional surgical operation. Conclusions: Based on our experience of this case series of rectal NETs, en bloc resection using ESD is a　promising treatment modality.

This study examined the association between non-invasive liver fibrosis biomarkers and non-alcoholic fatty liver disease (NAFLD) in an apparently healthy population. A matched case-control design was used to analyze 145 pairs of participants with and without NAFLD. Six liver fibrosis indexes were evaluated: Aspartate Aminotransferase to Alanine Aminotransferase Ratio (AAR), Aspartate Aminotransferase to Platelet Ratio Index (APRI), fibrosis index based on four factors (FIB-4), modified FIB-4 (mFIB-4), Forns Index, and Gamma-Glutamyl Transpeptidase to Platelet Ratio (GPR). Adjusted logistic regression analyses showed significant associations between mFIB-4 and Forns Index with NAFLD, highlighting their potential as tools for early detection. These markers demonstrated consistency across multiple analyses, supporting their potential use for screening asymptomatic individuals, especially in resource-limited settings. However, traditional markers like APRI and GPR showed limited utility in this cohort, emphasizing the need for contextual biomarker selection. Future studies should validate these findings across diverse populations and investigate their diagnostic capabilities in prospective cohort studies to improve early NAFLD detection and intervention.

医学祭特別企画講演 災害医療の現実とこれから～国際災害医療支援の経験から次世代へのメッセージ～/大場次郎 特別講演Ⅰ 自己完結型肝硬変再生療法までの道程と今後/高見太郎 特別講演Ⅱ ルーラルにみいだす看護の本質と人材育成山口県へき地医療対策地域をフィールドにした調査研究/牛尾裕子 中村賞受賞者講演 リアノジン受容体を標的としたドキソルビシン心筋症の革新的予防法/中村吉秀,山本健,小林茂樹,末冨建,内海仁志,矢野雅文,佐野元昭 小西賞受賞者講演 ICS/LABA治療下における喘息のClinical Remission達成率と関連因子の検討 −SEACON surveyより−/大石景士,濱田和希,深津愛祐美,村田順之,浅見麻紀,枝國信貴,平野綱彦,松永和人 学部学生演題No.１ 自己完結型肝硬変再生療法における間葉系幹細胞の肝再生液性因子発現の検討/三浦愛実，松本俊彦，高見太郎 学部学生演題No.２ ２型リアノジン受容体の安定化が実験的自己免疫性脳脊髄炎に与える影響の検討/藤野顕，辻竣也，坂本明彦，朝霧成挙 学部学生演題No.３ 大腸がん患者におけるpks+ E. coliの生理的意義の解明/伊勢美貴，鎌田信彦，海老原慎也，坂本啓，長谷川明洋 学部学生演題No.４ SERPING1遺伝子の新規病的バリアントの解析/池田美貴，下村裕 学部学生演題No.５ コルヒチン中毒の一剖検例/川口藍，二宮理紗，吉賀貴雄，神田聖文，姫宮彩子，髙瀬泉 一般演題No.６ MODY8の原因遺伝子CELの稀なミスセンス変異を有する若年発症糖尿病の１例/藤井綾菜，中林容子，濱田梨沙子，秋山優，永尾優子，田口昭彦，寄元海渡，　渡邉健司，水上洋一，太田康晴 一般演題No.７ Far-UVC photoporation法の開発/西村舞音，西川潤，清水勇輝，藤井智大，藤川穂乃香，末広寛，山﨑隆弘，山本健 一般演題No.８ 人工知能による表在型非乳頭部十二指腸上皮性腫瘍の異型度診断/山本一太，五嶋敦史，田中康行，浜本果歩，大木美穂，児玉愛実，山本美音，吉松祐希，青山将司，松本怜子，伊藤駿介，浜辺功一，橋本真一，西川潤，高見太郎 一般演題No.９ 臨床実装をめざした水素透析システムの確立/澁谷正樹，米澤眞子，西村夏実，藤中理史，谷健二，佐野元昭 一般演題No.10 多発性嚢胞腎発症における線毛膜コレステロールの病態生理学/板橋岳志，森田知佳，弘澤萌，宮本達雄 一般演題No.11 COPDにおける身体活動性低下を捉えるバイオマーカーとしての患者報告アウトカム尺度（PROMs）及びマイオカインの有用性の検討/山本佑，平野綱彦，深津愛祐美，土居恵子，濱田和希，村田順之，大石景士，浅見麻紀，枝國信貴，松永和人，髙橋浩一郎，浅井一久，佐々木誠悟，中西正典，南方良章 一般演題No.12 早産児におけるヒドロコルチゾン投与量と退院前頭部MRIのKidokoro scoreとの関連性の検討/兼安秀信，時髙留依，縄田慈子，濱野弘樹，向野文貴，坂田恭史，古田貴士，木村献，高橋一雅，長谷川俊史 大学院成績優秀者講演No.13 Spreading depolarizationに対する頭蓋内圧亢進と脳灌流圧の影響/西本拓真，岡史朗，井上貴雄，森山博史，川野伶緒，鈴木倫保，David Y Chung，Cenk Ayata，石原秀行 大学院成績優秀者講演No.14 メチル化HOXA1と腫瘍マーカーの組み合わせ検査は早期肝細胞癌において高い診断性能を示す/國宗勇希，末廣寛，佐伯一成，山内由里香，田邊規和，松本俊彦，西岡光昭，市原清志，永野浩昭，高見太郎，山﨑隆弘 大学院成績優秀者講演No.15 新規超音波ドプライメージングによる肝線維化診断法の確立/三浦大輔，末永弘美，間普真吾，市原清志