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HORIGUCHI Michiko


Comparative dissolution study of original and generic furosemide tablets

Bulletin of Sanyo-Onoda City University Issue 7 Page 39-43
published_at 2024-03-31
SU10007000005.pdf
[fulltext] 5.75 MB
Title
フロセミド錠の先発医薬品および後発医薬品の溶出性比較試験
Comparative dissolution study of original and generic furosemide tablets
Abstract
Furosemide is one of the most used loop diuretics. While several generic versions of furosemide tablets are available in clinical situation, similarities in dissolution property of these tablets have not been reported. Hence, we compared the differences of dissolution property of furosemide 40 mg tablets between the original and generic A in dissolution and disintegration tests.
Simple suspension of the generic A tablets showed a greater particle dispersion than that of the original product. The furosemide dissolution rate of generic A in the dissolution test showed a significant small compared to the original product during from 2 to 4 minutes after the beginning, but it became higher, in turn, at 30 minutes after. In the disintegration test, the generic A tablet had a longer disintegration time of 1-2 minutes than the original product. The generic A tablet contained specific additives of coating agents such as titanium dioxide, Hypromellose, and PEG6000. The presence of insoluble titanium dioxide causes white cloudiness in simple suspension of the generic A tablet. Both Hypromellose and PEG6000 were supposed to increases the dispersibility of furosemide, which could lead to the increased dissolution rate of the generic A tablet. These findings of this study on furosemide tablet are considered to provide helpful information for an alternative use with generic agents.
Creators TSURUDOME Yuya
Creators FUNAKI Tomoharu
Creators HORIGUCHI Michiko
Creators USHIJIMA Kentaro
Source Identifiers [PISSN] 2434-2866
Creator Keywords
Dissolution test Disintegration test branded generic drug 溶出試験 崩壊試験 後発医薬品
Languages jpn
Resource Type departmental bulletin paper
Publishers Sanyo-Onoda City University
Date Issued 2024-03-31
File Version Version of Record
Access Rights open access